2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Z1430S
    (3R,4S)-Paroxetine-d4 hydrochloride
    Paroxetine EP impurity D-d4 (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity).
    (3R,4S)-Paroxetine-d<sub>4</sub> hydrochloride
  • HY-N12843
    2-Deoxokanshone M
    2-Deoxokanshone M (Nardosinone acid) is a degradation product of Nardosinone (HY-N0380) and has potent vasodilatory activity.
    2-Deoxokanshone M
  • HY-117934
    Isokotanin B
    Isokotanin B is a metabolite of bicoumarin isolated from the sclerotia of Aspergillus alliaceus. Isokotanin B shows activity against the corn earworm Helicoverpa zea and the dried fruit bettle Carpophilus hemipterus.
    Isokotanin B
  • HY-78847R
    2R,4S-Sacubitril (Standard)
    2R,4S-Sacubitril (Standard) is the analytical standard of 2R,4S-Sacubitril. This product is intended for research and analytical applications. 2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    2R,4S-Sacubitril (Standard)
  • HY-137200
    N-Desmethyl Bendamustine
    N-Desmethyl Bendamustine is a metabolite of Bendamustine (HY-13567). N-Desmethyl Bendamustine has cytotoxic effect in several lymphoma cell lines and peripheral blood lymphocytes.
    N-Desmethyl Bendamustine
  • HY-172549
    Propofol sulfate sodium
    Propofol sulfate sodium is a metabolite of Propofol (HY-B0649).
    Propofol sulfate sodium
  • HY-116246
    5(S)-HETE lactone
    5(S)-HETE lactone is an arachidonic acid (AA) metabolite.
    5(S)-HETE lactone
  • HY-100635R
    Diacetolol (Standard)
    Oleic acid (Standard) is the analytical standard of Oleic acid. This product is intended for research and analytical applications. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
    Diacetolol (Standard)
  • HY-N0894B
    (3S,5S)-Octahydrocurcumin
    (3S,5S)-Octahydrocurcumin ((3S,5S)-Hexahydrobisdemethoxycurcumin) is a fungal metabolite that can be isolated from Curcuma longa.
    (3S,5S)-Octahydrocurcumin
  • HY-136611R
    ω-Hydroxy-DEET (Standard)
    Carbasalate calcium (Standard) is the analytical standard of Carbasalate calcium. This product is intended for research and analytical applications. Carbasalate calcium is an anti-inflammatory, antipyretic, and analgesic agent.
    ω-Hydroxy-DEET (Standard)
  • HY-131629
    N-Desmethyl-U-47700
    N-Desmethyl-U-47700 is the primary metabolite of U-47700 (an opioid agonist).
    N-Desmethyl-U-47700
  • HY-W777199
    Tianeptine metabolite MC5 sodium salt
    Tianeptine metabolite MC5 sodium salt is a major active metabolite of tianeptine. Tianeptine and MC5 metabolite are eliminated with bile as glucuronide and glutamine conjugates.
    Tianeptine metabolite MC5 sodium salt
  • HY-145480
    Silodosin Glucuronide sodium
    Silodosin Glucuronide sodium (Silodosin β-D-glucuronide sodium) is the metabolite of Silodosin (HY-10122). Silodosin is a selective and orally active antagonist for α1A-adrenergic receptor (α1A-AR) with Ki of 0.036 nM.
    Silodosin Glucuronide sodium
  • HY-137575R
    Terbutalone (Standard)
    Terbutalone (Standard) is the analytical standard of Terbutalone. This product is intended for research and analytical applications. Terbutalone is a derivative of Terbutaline (HY-B0802A). Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of Bambuterol (HY-17501). Terbutaline can be used in asthma symptom research.
    Terbutalone (Standard)
  • HY-19555AR
    Seco Rapamycin sodium salt (Standard)
    Phenglutarimid (hydrochloride) (Standard) is the analytical standard of Phenglutarimid (hydrochloride). This product is intended for research and analytical applications. Phenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
    Seco Rapamycin sodium salt (Standard)
  • HY-108251R
    Methotrexate metabolite (Standard)
    Methotrexate metabolite (Standard) is the analytical standard of Methotrexate metabolite. This product is intended for research and analytical applications. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.
    Methotrexate metabolite (Standard)
  • HY-G0014AR
    Quetiapine sulfoxide dihydrochloride (Standard)
    Quetiapine sulfoxide (dihydrochloride) (Standard) is the analytical standard of Quetiapine sulfoxide (dihydrochloride). This product is intended for research and analytical applications. Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[2].
    Quetiapine sulfoxide dihydrochloride (Standard)
  • HY-101403A
    Monoacetylcadaverine hydrochloride
    Monoacetylcadaverine hydrochloride is a metabolite of the endogenous polyamine cadaverine.
    Monoacetylcadaverine hydrochloride
  • HY-101108S1
    Tazarotenic acid-13C2,d2
    Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the 13C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
    Tazarotenic acid-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
  • HY-131257
    Gefitinib impurity 1
    		99.59%
    Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.
    Gefitinib impurity 1
Cat. No. Product Name / Synonyms Application Reactivity